A transient decrease in mitochondrial activity contributes to establish the ganglion cell fate in retina adapted for high acuity vision
Developmental Biology (2021) 469 : 96-110. https://doi.org/10.1016/j.ydbio.2020.10.002
Graphical Abstract
Highlights
- HES5.3 induces a transient decrease of mitochondrial activity in pre-committed retinal progenitors via the RA pathway.
- The transient HES5.3-mediated metabolic shift slows down the cell cycle progression of ATOH7+ pre-committed progenitors.
- HES5.3 decreases the level of RA, thus contributing to increase the fraction of ATOH7+ cells that are converted into RGCs.
- The recovery of mitochondrial activity coincides with the downregulation of HES5.3 and is required in newborn RGCs.
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