Delayed neurogenesis with respect to eye growth shapes the pigeon retina for high visual acuity

 

Development (2016) 143 : 4701-4712. https://doi.org/10.1242/dev.138719

Graphical Abstract

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Highlights

  • The genetic programs underlying cell differentiation are postponed in the pigeon retina until the end of the period of cell proliferation.
  • The late onset of neurogenesis has a profound effect on the developmental patterning of the pigeon retina.
  • The uncoupling of tissue growth and neurogenesis is shown to result from the fact that the pigeon retinal epithelium is inhibitory to cell differentiation.
  • The sum of these developmental features allows the pigeon to build a retina that displays the structural and functional traits typical of primate macula and fovea.

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